After studying Module 2: Lecture Materials & Resources, submit the following:
Starting with the precursor substance tyrosine or tryptophan, draw three diagrams showing how the various enzymes convert this substance to serotonin, dopamine and norepinephrine.
How to solve
NUR 520 Florida International University Health and Medical Project
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Introduction:
In this assignment, you are required to draw three diagrams showing the conversion of the precursor substances tyrosine or tryptophan to serotonin, dopamine, and norepinephrine. These neurotransmitters play crucial roles in the central nervous system and are involved in various physiological processes. By understanding the enzymatic conversion pathways, you will gain insights into the synthesis of these important neurotransmitters.
Answer:
Diagram 1: Conversion of Tyrosine to Dopamine
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Tyrosine -(Enzyme: Tyrosine Hydroxylase)-> L-DOPA -(Enzyme: DOPA Decarboxylase)-> Dopamine
Explanation: Tyrosine is converted into L-DOPA by the enzyme called Tyrosine Hydroxylase. Further, L-DOPA undergoes decarboxylation by DOPA Decarboxylase enzyme to form Dopamine.
Diagram 2: Conversion of L-Tryptophan to Serotonin
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L-Tryptophan -(Enzyme: Tryptophan Hydroxylase)-> 5-Hydroxytryptophan (5-HTP) -(Enzyme: Aromatic L-Amino Acid Decarboxylase)-> Serotonin
Explanation: L-Tryptophan is converted into 5-Hydroxytryptophan (5-HTP) by the enzyme Tryptophan Hydroxylase. Further, 5-HTP undergoes decarboxylation by Aromatic L-Amino Acid Decarboxylase enzyme to form Serotonin.
Diagram 3: Conversion of Tyrosine to Norepinephrine
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Tyrosine -(Enzyme: Tyrosine Hydroxylase)-> L-DOPA -(Enzyme: Dopamine β-Hydroxylase)-> Norepinephrine
Explanation: Tyrosine is converted into L-DOPA by the enzyme called Tyrosine Hydroxylase. Further, L-DOPA undergoes hydroxylation by Dopamine β-Hydroxylase enzyme to form Norepinephrine.
It is important to note that these conversions are simplified representations of the complex biochemical pathways involved in the synthesis of serotonin, dopamine, and norepinephrine. Understanding these pathways provides insights into the regulation of neurotransmitter levels and can be crucial in the management of various neurological and psychiatric disorders.
